Major gene expression events of Plasmodium falciparum pathogenicity
نویسندگان
چکیده
منابع مشابه
Regulation of gene expression in Plasmodium falciparum
With the ability to adopt an assortment of forms throughout its life cycle, and to thrive in host environments so diverse and challenging, the malaria parasite Plasmodium falciparum may well serve as the epitome of the regulation of gene expression. The parasite is replete with mechanisms of control, many of them unique and intriguing, permitting it to transit seamlessly from one defined ecolog...
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ABSTRACT Our objective was to provide functional characterization of gene expression related to Intraerythrocytic Developmental Cycle (IDC) of Plasmodium Falciparum. We explored a hypothesis that genes with same or similar function are likely to have similar expression profiles. Analysis of 1,051 Gene Ontology (GO) terms represented by at least two genes in Plasmodium Falciparum microarray data...
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BACKGROUND Pregnancy-associated malaria (PAM) causing maternal anemia and low birth weight is among the multiple manifestations of Plasmodium falciparum malaria. Infected erythrocytes (iEs) can acquire various adhesive properties that mediate the clinical severity of malaria. Recent advances on the molecular basis of virulence and immune evasion have helped identify var2csa as a PAM-specific va...
متن کاملgenetic diversity in the circumsporozoite protein gene of plasmodium falciparum from major endemic regions of iran
circumsporozoite protein (csp) is one of the stage specific antigens, which is used for the development of vaccines and to investigate the genetic diversity in plasmodium falciparum malaria parasite. polymerase chain reaction was used for typing of csp genes on 67 positive falciparum malaria patients from sistan and baluchistan province of iran. three fragments were detected for csp gene. twent...
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To examine human gene expression during uncomplicated P. falciparum malaria, we obtained three samples (acute illness, treatment, and recovery) from 10 subjects and utilized each subject's recovery sample as their baseline. At the time of acute illness (day 1), subjects had upregulation of innate immune response, cytokine, and inflammation-related genes (IL-1β, IL-6, TNF, and IFN-γ), which was ...
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2019
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2018.11.349